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New to BFS? Start with Our Video Series

Blow-Fill-Seal: An Advanced
Aseptic Fill-Finish Process

A Highly-Efficient and Reliable Aseptic Process

Blow-Fill-Seal: A Highly-Efficient
and Reliable Aseptic Process

Efficient Manufacturing Process Infographic

New to BFS? Start with Our Video Series

New to Blow-Fill-Seal? Start with
Our Video Series

Introduction to Blow-Fill-Seal

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At the center of ApiJect's design and technical solutions is Blow-Fill-Seal, an industry-recognized advanced aseptic fill-finish process for sterile liquids.

About Blow-Fill-Seal

Blow-Fill-Seal (BFS) is a globally-trusted aseptic packaging technology where the pharmaceutical-grade plastic container is made, filled with the liquid drug product, and sealed in a rapid, continuous process.

BFS is used around the world to package billions of doses of both large and small molecule sterile drug products annually, including vaccines.

Advantages of Blow-Fill-Seal

The rotary BFS machines made by Rommelag® that ApiJect primarily designs its technology for several potential advantages over more traditional fill-finish processes, including:

  • Very efficient with almost no human intervention
  • Compact resilient supply chain
  • Scalable manufacturing for development and commercial
  • Aseptic filling in a closed ISO-5 environment
  • Single primary raw material: pharmaceutical-grade polymer resin
  • No glass particulates or shards
  • Lightweight and resistant to breakage
  • Cost-effective unit-dose filling
  • Highly-customizable container shapes and volumes

Advancing Blow-Fill-Seal for More Drug Products

At ApiJect, we are advancing Blow-Fill-Seal so that it can be the primary container that delivers a wide range of parenteral medicines and vaccines. This will allow more pharmaceutical and biotech companies to consider using BFS as a suitable aseptic filling process for their liquid drug products.

For example, at the new ApiJect Technology Development Center in the greater Orlando, FL area, our engineers are devising new processes to better control the temperature of the drug product throughout the BFS process. Likewise, our experts are a range of BFS mold sizes and configurations, with testing on both a small-scale Weiler® Lab+ shuttle BFS machine as well as a Rommelag® Bottelpack 434 rotary BFS machine.

In addition, our engineers are developing and testing various needle hubs and other components that can be attached directly to the BFS container, enabling inline delivery of the drug product without transfer to a syringe or other external delivery system.

Additional Technical Resources

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Learn more about how ApiJect works with pharma,
biotech companies, and contract manufacturers

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BFS IOA
PBOA
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